INS and obesity due to melanocortin 4 receptor deficiency: Considering the mean value for each parameter defined as EGIR metabolic syndrome criteria (glucose > 6.1 mmol/l, HDL-C < 1 mmol/l, insulin >18 mUI/l (QR4), and waist circumference > 80 cm), neither overweight nor obesity subgroups met the three required criteria [18].