EMT regulation and PCa progression are also mediated by targeted downregulation through the loss of miR-154 due to stromal antigen 2 (STAG2), the loss of miR-203 due to tumor growth factor-alpha (TGF-α), and the loss of miR-224 due to Tribbles Pseudokinase 1 (TRIB1) [103, 104]. This evidence concerns the gene STAG2 and posterior cortical atrophy.