To determine whether Notch-Hes1 signaling can regulate the function of IL-17A+γδ+T cells within the disease situation of psoriasis, we inhibit Notch-Hes1 signaling by γ-secretase inhibitor DAPT to determine the possible regulating function of Notch-Hes1 signaling on IL-17A+γδ+T cell expression and IL-17A secretion in mouse psoriasis-like skin inflammation. The gene discussed is HES1; the disease is psoriasis.