HJV is a glycophosphatidylinositol- (GPI-) anchored protein [55]; MT-2 cleavage the membrane HJV (m-HJV) to a form of soluble HJV (s-HJV) to decreases the affinity for BMP6 [56]; thus, the MT-2 expression increases during iron deficiency [57]. Here, TMPRSS6 is linked to Iron deficiency anemia.