TNF and cancer: Enrichment analyses of the expanded genes revealed that they were enriched in 40 GO terms and 20 KEGG pathways (see Figure 3B; Tables S35 and S36), primarily in association with immune systems (such as “proteoglycans in cancer,” “scavenger receptor activity,” “salmonella infection,” “TNF signaling pathway,” and “PI3K-Akt signaling pathway”; see Table S37) and redox processes (such as “oxidoreductase activity,” “oxidation-reduction process,” and “flavin adenine dinucleotide binding”; see Table S38), indicative of adaptation to burial in sediment environments.