A number of immune-related genes were expanded in two buried bivalves, including interferon-inducible GTPase 5 (Iigp5) and heat shock protein 70 (Hsp70) member 12 (Hsp70_12), and they were enriched in “TNF signaling pathway” and “proteoglycans in cancer,” respectively. The gene discussed is IRGC; the disease is cancer.