,48 However, using a panel of HIV-specific (CD4-based) CARs expressing distinct intracellular domains (ICDs), we show that only HIV-resistant, 4-1BB-costimulated CAR4 T cells limit in vivo HIV infection, congruent with our previous work identifying 4-1BB as the optimal ICD for HIV-specific CAR8 T cells.36 The gene discussed is CD4; the disease is HIV infectious disease.