Lipodystrophic lamin A R482 W mutation perturbs chromatin conformation at an anti-adipogenic microRNA locus in adipose progenitor cells and EDMD causing R453 W mutant alters the lamin-associated domains (LADs) and lamin-Polycomb repressor complex interactions [104]. Here, LMNA is linked to Emery-Dreifuss muscular dystrophy.