RYR2 and ischemia: The effect of IXA on post-ischemia mitochondrial function has not been investigated before and since this inhibitor effectively protected RyR2, one of the proteins involved in the SR-mitochondrial association, we aimed to determine whether Mfn2 degradation can be prevented by IXA; and to evaluate the effect of the drug on the functional and morphologic changes to the mitochondria that occur during ischemia but before reperfusion in isolated rat hearts.