Our findings demonstrated significantly up-regulated *(P < 0.05) expression of the toxic Aβ mOC64 form, APP, HIF-1α, as well as p-Tau in the brains of various groups of patients infected with HIV (asymptomatic as well as minor cognitive impairment, AD, cerebral ischemia) compared to uninfected individuals. This evidence concerns the gene HIF1A and brain ischemia.