We compared the genes identified in this analysis with the DMPs and DEGs detected in the between-island comparisons, and find that 218 genes (17.16% of DEGs; hypergeometric p = 1.9x10-14) in the comparison between Korowai and Sumba, 193 genes (15.20%, p = 4.9x10-22) between Korowai and Mentawai, and 37 genes (2.91%, p = 0.203) between Sumba and Mentawai have expression levels associated with significant methylation changes at nearby CpGs; these include genes like SIGLEC7 (Fig 3B), which is involved in antigen presentation and natural killer (NK) cell-dependent tumor immunosurveillance [53]. This evidence concerns the gene SIGLEC7 and neoplasm.