Of the CHD subfamily III, CHD7 regulates developmental hematopoiesis [38] and expansion of hematopoietic stem and progenitor cells, whereas CHD8 is required for survival of both non-transformed pre-B cells and acute lymphoblastic B-cell leukemia cells as well as EμMyc B-cell lymphomas [39]. The gene discussed is CHD7; the disease is B-cell acute lymphoblastic leukemia.