MYL2 and familial dilated cardiomyopathy: Transgenic mice overexpressing an HCM-associated missense variant MYL2:p.E22K showed an enlarged interventricular septum and papillary muscle but failed to display sarcomeric disarray or echocardiographic changes in myocardial thickness or function [60], while transgenic mice overexpressing the DCM variant MYL2:p.D94A display dilation of the left ventricular chamber, decreased ejection fraction and mild ventricular systolic dysfunction similar to that observed in patient with the same variant [53, 61].