Furthermore, when this univariate Cox model analysis was adjusted for KPS, BMI, disease stage and TNM stage, the result demonstrated that CTNNB1: rs1880481 with the AC/ AA genotype was also significantly correlated with a decreased risk of bone metastasis (HR = 0.742, 95% CI=0.592-0.929, p = 0.009). The gene discussed is CTNNB1; the disease is bone metastasis.