To explore the combined role of decreased risk SNPs in bone metastasis in NSCLC patients, we defined a genotype with HR of less than 1 as being a “protective” SNP, which included WNT2: rs6947329, AXIN1: rs214252, CTNNB1: rs1880481, CTNNB1: rs4135385 and APC: rs454886. This evidence concerns the gene CTNNB1 and non-small cell lung carcinoma.