To analyze the association between protective SNPs and NSCLC bone metastasis development, the distribution of clinical characteristics, such as sex, age, smoking status, BMI, T status, N status, M status, clinical stage, tumor histology, and KPS score, in patients with bone metastasis carrying CTNNB1: rs1880481 was valuated. This evidence concerns the gene CTNNB1 and non-small cell lung carcinoma.