Interestingly, while the allosteric inhibitor MK-2206 predictably shows marginal inhibition of AKT1-E17K, two other allosteric AKT inhibitors, ARQ 092 and ARQ 751, have demonstrated potency against this mutant, excellent anti-tumour activity both in cell lines and PDX models [32], and promising results in early phase studies, including in a patient with an E17K mutation [33]. Here, AKT1 is linked to neoplasm.