BRCA1 and breast cancer: The present studyinvestigated in North Indian breast cancer patients the association of risk withfour reported pathogenic variants of BRCA1: c.190T>C(p.Cys64Arg), 1307delT, g.5331G>A (p.G1738R) and c.2612C>T (p.Pro871Leu).Genotyping was done by PCR-RFLP method in 255 clinically confirmed breast cancerpatients and 255 age and gender matched healthy individuals.