Enhancer of zeste homolog 2 (EZH2), a member of polycomb repressive complex 2 (PRC2),trimethylates lysine 27 of histone H3 (H3K27me3) and regulates several genesinvolved in tumor development (Chang and Hung,2012; Wen et al.,2017). The gene discussed is EZH2; the disease is neoplasm.