We ectopically introduced HA-tagged EZH2 protein inUSP7-knockdown cell lines (Figure 5A andFigure S3A).Cell migration, invasion, and sphere-forming activities were restored by EZH2overexpression in USP7-knockdown prostate cancer cells (Figure 5B-E and FigureS3B-E). This evidence concerns the gene USP7 and Familial prostate cancer.