However, so far, no attempt has been made to investigate thechanges in the migratory and invasive potential in vitro bysimultaneously treating cells with USP7-specific inhibitor and EZH2 inhibitor.We speculated that the reduction of EZH2 protein by USP7 inhibitor couldmodulate the sensitivity of EZH2 inhibitors in prostate cancer cells. Here, EZH2 is linked to prostate cancer.