Lung cancer also presents decreased expression of DUOX1 and DUOX2 that iscorrelated with hypermethylation of CpG-rich promoter regions of DUOX genes.Moreover, DUOXA1 and DUOXA2 weredown-regulated in lung cancer cells and lung cancer tissues (Luxen et al., 2008). This evidence concerns the gene DUOXA2 and lung cancer.