DUOX2 and colonic neoplasm: In this cell line, H2O2 producedby DUOX was responsible for inactivating protein phosphatases, which maintainedthe phosphorylation of AKT and glycogen synthase kinase 3β (Pettigrew et al., 2013).Kang et al. (2018)showed that DUOX2-derived H2O2 mediates 5-Fluorouracil(FU)-resistance in colon cancer cells.