ERCC6 and Cowden syndrome 1: Zebrafish with the CSB depleted by morpholino oligonucleotides at the larval stageshow an increased frequency of morphological abnormalities, which may recapitulatesome of the congenital and developmental manifestations seen in patients with CS.Ionizing radiation can further increase morphological aberrations in CSB-depletedzebrafish, thereby pointing to an important role of CSB in the defense againstoxidative DNA damage (Wei et al.,2015).