For example, Cosmc knockdown has been previously reported to enhance oncogenic properties in pancreatic cancer through an accumulation of aberrant O-glycosylation substrates and, increased Tn antigen expression was detected in Cosmc deficient pancreatic ductal adenocarcinoma (PDAC) cells [9]. This evidence concerns the gene C1GALT1C1 and pancreatic ductal adenocarcinoma.