As an example, NPR1 interacts with atrial natriuretic peptide, which is an endogenous and physiological peptide, and atrial natriuretic peptide has significant antitumour effect in multiple cancers such as pancreatic cancer, breast cancer, small cell lung cancer, prostate cancer and colorectal cancer.61, 62. The gene discussed is NPPA; the disease is Familial prostate cancer.