While neither of these mutations have been described frequently in anaplastic ganglioglioma or diffuse midline glioma H3 K27M mutant, they both may point towards higher malignancy: The Y849 position of PDGFRα is of functional importance [17] and aberrant expression of PDGFRα [18] and TERT promoter mutations typically are frequently observed in glioblastoma, however, TERT promoter mutations also occur very frequently in oligodendroglioma WHO grade II [19, 20]. This evidence concerns the gene PDGFRA and diffuse midline glioma.