In addition, serum cytokine levels, such as IL-6, correlate with poor CRC outcomes, suggesting that a patient’s systemic inflammatory response to CRC may also be linked to their ability to survive the disease.6 Surprisingly, whether the composition of the TME or serum cytokine responses from patients with CRC differ based on sex is not known, despite the difference in survival noted in this disease. Here, IL6 is linked to colorectal carcinoma.