This form of cytotoxicity is supported by a previous study showing elevated granzyme B accumulation in the CD103+ T-cell immunological synapse.112,113 Using live cell imaging, we further demonstrated that CD103+ CTA-specific CTLs induce faster E-cadherin+ cancer cell killing compared with the TCR-matched CD103− CTLs.108 This rapid killing allowed significantly higher numbers of accumulative E-cadherin+ cancer cell deaths over time. Here, GZMB is linked to cancer.