However, CTAs are frequently expressed on cancer cells.30 Human CTAs, such as synovial sarcoma X-2 (SSX-2), New York-esophageal squamous cell carcinoma-1 (NY-ESO-1), and melanoma associated antigen A-1 or A-3 are over-expressed in different human cancers such as in melanoma and lung cancer.31–33 CTA-specific T cells are frequently detected in cancer patients and contribute to tumor regression. The gene discussed is SSX2; the disease is cancer.