The analysis of fresh CRC specimens (Supplementary Table 1) indicated an increased infiltration of CD4+ T cells producing IL-22 by trend compared with adjacent normal colon tissue (frequency of IL-22-producing cells within CD4+ T cells: control: 5.09±5.5 vs tumor: 7.68±6.21, p = 0.0879). This evidence concerns the gene CD4 and colorectal carcinoma.