However, the effect was heterogeneous and the extent of HER3 mRNA reduction in SATB1 depleted cells was cell line dependent, again with minor changes in UT-SCC-16B cells that in general had remained rather unaffected by SATB1 knockdown, while HER3 mRNA levels were found reduced up to ~ 50% for example in UT-SCC-15 cells where siSATB1 had shown profound tumor cell inhibition. Here, SATB1 is linked to neoplasm.