Leading edge analyses implicated various co-enriched activin-regulated genes in pathological scar formation, including Postn, Cthrc1 (encoding collagen triple helix repeat containing 1, which is overexpressed in human keloids and keloid-derived fibroblasts38) and Sfrp2 (encoding secreted frizzled-related protein 2, a marker of pro-fibrotic fibroblasts in human skin39) in keloid fibroblasts and wound myofibroblasts, and Lox and Plod2 in wound myofibroblasts (Supplementary Fig. 3e). This evidence concerns the gene PLOD2 and keloid.