In some cases, chromatin decondensation and disease-specific differential expression of formerly LAD-associated loci accompanies their relocalization within the nucleus (Fig. 6), as detected for EDIL3 and IGFBP7. Further experiments are needed to clarify whether similar mechanisms contribute to disease-specific gene expression in other tissues and in other laminopathies. Here, IGFBP7 is linked to laminopathy.