DNMT3B and Hutchinson-Gilford progeria syndrome: Using a previously published ChIP-seq dataset [51], we also noticed that DNMT3B, but not DNMT3A, is significantly enriched in genomic regions associated with lamin A (P < 2.20e−16, Wilcoxon test, Additional file 1: Fig. S15), thus providing a potential mechanistic link to the observed DNA methylation changes in HGPS cells.