Injection of Bayk8644 in FXR KO mice (28.0 ± 9.4 mm3) illustrated larger infarct volume at 3 days after stroke and brain atrophy volume (5.3 ± 1.0 mm3) compared to FXR KO group (Fig. 6b, c). This evidence concerns the gene NR1H4 and Brain atrophy.