The top 13 (Count Number ≥ 12) pathways included cancer, hepatitis B, PI3K-AKT, neuroactive ligand-receptor interactions, HTLV-I infection, TNF, influenza A, cAMP, proteoglycans in cancer, MAPK, non-alcoholic fatty liver disease, viral carcinogenesis and microRNAs in cancer signaling pathways. This evidence concerns the gene PIK3CA and hepatitis B virus infection.