UCP1 and obesity due to melanocortin 4 receptor deficiency: detected three other point mutations in the coding region of the Ucp1 gene: Arg40Trp (rs573078239) in exon 1 and Lys257Arg (rs1431343082) and Met229Leu (rs2270565) in exon 5, but none of them showed an association with the development of obesity (Hamann et al. 1998).