Similar to previous studies, the VAF of the CH‐related mutations detected in the tumor tissues in our study was significantly lower than the cancer cell‐derived mutations, possibly due to the lower number of white blood cells compared to the tumor cells in the tissues (Coombs et al., 2018; Kleppe et al., 2015; Li et al., 2017; Ptashkin et al., 2018). This evidence concerns the gene C4B and neoplasm.