Masayuki et al. screened out 15 downregulated miRNAs of the 365 miRNAs in ESCC tissues.21 In cholangiocarcinoma, Wan et al. found HEIH exhibited a positive role in regulating cell proliferation, invasion and migration by inhibiting miR‐98‐5p and upregulating HECTD4.22 In our study, we speculated that HEIH interacted with miR‐4458. The gene discussed is HECTD4; the disease is cholangiocarcinoma.