Parallel with our findings, PBX3 was also found to be regulated by miR‐4458 in tumorigenesis of melanoma.26 Furthermore, silencing of PBX3 inhibited cell proliferation and invasion of EC109 cells, while miR‐4458 mimics or HEIH vector both migrated the inhibitory effects stimulated by si‐PBX3. This evidence concerns the gene PBX3 and melanoma.