These mice display social interaction deficits, impaired spatial learning and recognition memory, reduced anxiety, and enhanced locomotor coordination (Table 1). Gene expression profiling reveals altered expression of genes encoding GABAA receptor subunits, along with several autism spectrum disorder (ASD)-related genes such as SH3 and multiple ankyrin repeat domains protein 3 (Shank3), Forkhead box protein P2 (Foxp2), and myocyte-specific enhancer factor 2c (Mef2c). Here, SHANK3 is linked to Anxiety.