However, at the age of 6 months, when the impairments of the Tg mice become more pronounced (Tsai et al, 2010), we observed obvious co‐mislocalization of TDP‐43 and HDAC1 from the nucleus to the cytosol, which corresponded to the pathogenesis of TDP‐43 proteinopathies. This evidence concerns the gene HDAC1 and proteostasis deficiencies.