Quantified results from the frontal cortices indicated that the number of cells or neurons with aberrant cell cycle activity was significantly increased in FTLD‐TDP Tg mice (Fig 1B) and strongly correlated with TDP‐43 proteinopathies, since aberrant cell cycle activity cannot be detected without TDP‐43 mislocalization at the age of 2 months of FTLD‐TDP Tg mice (Fig EV1), which imply that TDP‐43 proteinopathies precede the onset of cell cycle aberrance. This evidence concerns the gene TARDBP and proteostasis deficiencies.