TARDBP and proteostasis deficiencies: Furthermore, IF staining of Ki67 and γH2AX (Fig 2C, upper graph) in the frontal cortices and hippocampus of 6‐mon‐old FTLD‐TDP Tg and WT mice further revealed that cells/neurons with aberrant cell cycle activity also suffered DNA damage, which suggests that both pathological features are involved in TDP‐43 proteinopathies.