Smoking, history of MI, RBP-4 ≥4 ng/ml, LCI ≥16 and RBP-4 + LCI were found to be independent risk factors of 1 lesion vessel; hypertension, diabetes mellitus, smoking, history of MI, RBP-4 ≥4 ng/ml, LCI ≥16 and RBP-4 + LCI were independent risk factors of 2 lesion vessels; and finally, hypertension, diabetes mellitus, smoking, history of MI, RBP-4 ≥4 ng/ml, LCI ≥16 and RBP-4 + LCI were independent risk factors of 3 lesion vessels (all p < 0.05). This evidence concerns the gene RBP4 and hypertensive disorder.