Chronic high-sugar feeding disturbs the balance of cell proliferation in the gut and leads to an increased number of Actβ-secreting cells; this extra Actβ induces abnormally high fat-body expression of AkhR, which triggers aberrant lipolysis and gluconeogenesis, thereby leading to carbohydrate imbalance and hyperglycemia [170]. Here, ACTB is linked to Hyperglycemia.