For the immune blood-based biomarkers, IgG1, IgG2, IgG3, and anti-cardiolipin antibodies A (ACA A) showed the best properties for discriminating BD from controls, and cytomegalovirus (CMV), herpes simples virus 2 (HSV2), and Toxoplasma Gondii for SZ from controls. This evidence concerns the gene IGHG3 and Behcet disease.