Experience has shown that twice daily treatment with the most widely used mixture of 30% soluble human insulin (HI) and 70% protamine-crystallized human insulin (NPH); Biphasic Human Insulin 30 (BHI 30) partially may compensate for hyperglycemia after breakfast and dinner, as well as provide sufficient basal insulin requirements until the next injection [3]. The gene discussed is INS; the disease is Hyperglycemia.