CD30 expression in PTCL suggests a CD30-mediated pathogenic mechanism for potential therapeutic targeting with brentuximab vedotin (BV), an antibody-drug conjugate that combines cytotoxic monomethylauristatin E (MMAE) with an anti-CD30 antibody [14]. The gene discussed is TNFRSF8; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.