In non-ALCL, single-agent BV showed clinical antitumor activity in AITL and PTCL-NOS, with ORR of 41% (including 54% ORR in AITL with a median PFS of 6.7 months), although responses did not correlate with CD30 expression [16]. Here, TNFRSF8 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.