Efforts to improve frontline therapy in PTCL have been focused on several strategies: (1) to improve upon CHOP by incorporating novel agent X into CHOP chemotherapy backbone, whereas X denotes therapeutic targeting of surface biomarkers such as CD30 and CD52, or epigenetic modifiers regulating essential pathogenic pathways involving modification of histone acetylation and methylation; (2) to explore novel combination free of conventional chemotherapy; and (3) to experiment with novel agents for consolidation and maintenance following chemotherapy induction. This evidence concerns the gene CD52 and mature T-cell and NK-cell non-Hodgkin lymphoma.