As the toxic properties of mHTT have been linked to elevation of nuclear factor-kappaB (NF-κB) activity [11], which is a potent inducer of IL-6 gene expression [12], mHTT-mediated upregulation of this pro-inflammatory cytokine in particular may lead to activation of neurotoxic innate immune signaling in HD. The gene discussed is IL6; the disease is Huntington disease.