EZH2 and diffuse large B-cell lymphoma: For example, in 22% of the germinal central B cell (GCB) subtype of diffuse large B cell lymphoma (DLBCL) and in 7% to 12% of follicular lymphoma (FL), a recurrent heterozygosity mutation is observed in the tyrosine (Y641) of the SET domain of EZH2 [18, 19].