EZH2 and neoplasm: This blocks the transcription of EAF2 and activates the HIF1α signaling pathway inducing the transcription of downstream genes involved in metabolism such as HK2, glucose transporter 1 (GLUT1), and PDK1. Therefore, it can be stated that EZH2 can facilitate tumorigenesis and the malignant progression of tumor cells through induction of the Warburg effect [45].