EZH2 and myelodysplastic syndrome: However, in cases of myelodysplastic syndrome (MDS) [24], myeloproliferative tumor (MPN) [25], and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) [26], it has been found that loss-of-function mutations in EZH2 could lead to the upregulation of certain oncogenic genes.