However, it has been reported that suppressing the activity of SAH hydrolase (such as DZNep) or hindering the linkage of EZH2 with SAM can significantly downregulate the global H3K27me3, leading to the inhibition of tumor cell (such as breast, bladder, and lung cancers) survival [71, 72]. The gene discussed is EZH2; the disease is lung carcinoma.