In relevant mechanism, both qRT-PCR and WB analysis showed that the mRNA and protein levels of Col-III, α-SMA and fibronectin were significantly increased in the mice lung tissues of model group, but were decreased under the action of PFD, whereas the addition of β-catenin promoted the mRNA and protein levels of Col-III, α-SMA and fibronectin (P < 0.01, Fig. 2a-c). The gene discussed is FN1; the disease is polyostotic fibrous dysplasia.