Moreover, a study conducted by Obermann et al. in 32 patients with whiplash injury without pre-existing headaches, found that patients who developed persistent PTH, compared to healthy controls and patients affected by acute PTH, showed a decreased anterior cingulate and dorsolateral prefrontal cortex (DLPFC) gray matter density, areas of the default mode and salience network [37]. The gene discussed is PTH; the disease is Headache.