Although phenotypic similarities between migraine and PTH have been demonstrated in previous studies, i.e. throbbing headache, pain on one side of the head, headache exacerbated by physical activities, moderate to severe pain, headache accompanied by nausea or vomiting, and photophobia and/or phonophobia [18–22], the exact relationship between persistent PTH and migraine remain largely unknown and the shared pathophysiological mechanisms are conflicting [23]. This evidence concerns the gene PTH and migraine disorder.