Furthermore, the gene Nr5a2, after secondary transition specifically regional expressed in the tip region of the pancreatic epithelium, is described in the context of cancer progression as being upregulated and suggests to inhibiting EMT and thus, inhibit cancer progression in the pancreas [7] whereas Sox9 is directly linked to PDAC, but only present in a minor subpopulation of approximately 0.8% and not determined for the PDAC progenitor of PanINs [19]. Here, SOX9 is linked to cancer.