Mutations of TP63 are associated with various developmental disorders, including ectrodactyly–ectodermal dysplasia–cleftlip/palate (EEC) syndrome [53], ankyloblepharon–ectodermal defects–cleft lip/palate (AEC) syndrome and split-hand/foot malformation-IV syndrome. The gene discussed is TP63; the disease is cleft lip/palate.