However, given the reported [60] reduction in alpha-cell SSTR2 protein expression (although a previous study [55] reported an increase in SSTR2 mRNA in islets from T2D human donors), we suggest that the reduction in SSTR2 protein in diabetes is secondary to the as-yet-unknown primary change in SST signalling in the prediabetic state. The gene discussed is SSTR2; the disease is type 2 diabetes mellitus.