Finally, in order to study the interactions and the hub genes of DEGs that are involved in CPIP and other neuropathic pain models, we carried out PPI network analysis of these 24 genes and found that the major hub genes deduced from PPI analysis include Cd53, Aif1, C1qc, C1qa, C1qb, Fcgr3a, and Fcgr2b (Fig. 7b). This evidence concerns the gene CD53 and neuropathic pain.