AIF1 and neuropathic pain: Finally, in order to study the interactions and the hub genes of DEGs that are involved in CPIP and other neuropathic pain models, we carried out PPI network analysis of these 24 genes and found that the major hub genes deduced from PPI analysis include Cd53, Aif1, C1qc, C1qa, C1qb, Fcgr3a, and Fcgr2b (Fig. 7b).