Similarly, co-expression of PDI-WT resulted in significantly fewer cells with cytoplasmic TDP-43M337V (13%–4%, p < 0.05, Figure 10C), whereas the ALS-mutants PDI-D292N (15%) and PDI-R300H (12%) had no effect, implying they were not protective against TDP-43 cytoplasmic mislocalization (Figure 10D). The gene discussed is P4HB; the disease is amyotrophic lateral sclerosis.