MARK2 and Alzheimer disease: Both MARK2 and VAC14, jointly involved in the genetic aetiology of AD and BIP, have been described to play a role in neuronal migration, tau phosphorylation (Gu et al., 2013; Matenia and Mandelkow, 2009; Reiner et al., 2009) and endosomal homeostasis (Di Paolo and De Camilli, 2006), whereas the regulation of gene expression in relation to enhancer activity might play a crucial role in the shared heritability of AD and cancer (Feng et al., 2017).