VAC14 and Alzheimer disease: There have also been a number of studies showing genetic overlap between AD and non-neurodegenerative disorders; in particular AD and bipolar disorder (BIP), implicating the MARK2 and VAC14 genes using cFDR analysis (Drange et al., 2019), AD and breast and lung cancer using LDSC (rg = 0.18, p = .03 and rg = 0.30, p = .01, respectively) (Feng et al., 2017), and AD family history and depression, although this showed a non-significant correlation (Gibson et al., 2017).