When multiple linear regression analysis was performed after adjusting for gender, age, hypertension, diabetes, coronary heart disease (CHD), neutral cells, platelets, creatine, homocysteine, prothrombin time, antihypertensive drugs, lipid-lowering drugs, and antiplatelet drugs, the beta coefficient (95%) of RDW-SD was 0.26 (0.15-0.38, p<0.001) in all included patients, which showed that the association between RDW-SD and serum NSE level was statistically significant. This evidence concerns the gene ENO2 and Hypertension.